Elimination of MYCN-Amplified Neuroblastoma Cells by Telomerase-Targeted Oncolytic Virus via MYCN Suppression.
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ABSTRACT: MYCN-amplified neuroblastoma (NB) cells exhibit transcriptional activation of human telomerase reverse transcriptase (hTERT) expression. hTERT promoter-driven oncolytic adenoviruses OBP-301 and OBP-702 exhibited a strong antitumor effect in human MYCN-amplified NB cells via induction of autophagy and E2F1-mediated MYCN suppression.
SUBMITTER: Tanimoto T
PROVIDER: S-EPMC7321810 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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