Ontology highlight
ABSTRACT:
SUBMITTER: Sansbury BE
PROVIDER: S-EPMC7321964 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Sansbury Brian E BE Li Xiaofeng X Wong Blenda B Patsalos Andreas A Giannakis Nikolas N Zhang Michael J MJ Nagy Laszlo L Spite Matthew M
Proceedings of the National Academy of Sciences of the United States of America 20200608 25
Ischemic injury initiates a sterile inflammatory response that ultimately participates in the repair and recovery of tissue perfusion. Macrophages are required for perfusion recovery during ischemia, in part because they produce growth factors that aid in vascular remodeling. The input signals governing this pro-revascularization phenotype remain of interest. Here we found that hindlimb ischemia increases levels of resolvin D1 (RvD1), an inflammation-resolving lipid mediator that targets macroph ...[more]