Ontology highlight
ABSTRACT:
SUBMITTER: Marinko JT
PROVIDER: S-EPMC7322011 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Marinko Justin T JT Kenworthy Anne K AK Sanders Charles R CR
Proceedings of the National Academy of Sciences of the United States of America 20200608 25
The ordered environment of cholesterol-rich membrane nanodomains is thought to exclude many transmembrane (TM) proteins. Nevertheless, some multispan helical transmembrane proteins have been proposed to partition into these environments. Here, giant plasma membrane vesicles (GPMVs) were employed to quantitatively show that the helical tetraspan peripheral myelin protein 22 (PMP22) exhibits a pronounced preference for, promotes the formation of, and stabilizes ordered membrane domains. Neither S- ...[more]