Co-targeting Mitochondrial Ca2+ Homeostasis and Autophagy Enhances Cancer Cells' Chemosensitivity.
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ABSTRACT:
SUBMITTER: Dubois C
PROVIDER: S-EPMC7322071 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Publications
Co-targeting Mitochondrial Ca<sup>2+</sup> Homeostasis and Autophagy Enhances Cancer Cells' Chemosensitivity.
Dubois Charlotte C Kondratskyi Artem A Bidaux Gabriel G Noyer Lucile L Vancauwenberghe Eric E Farfariello Valério V Toillon Robert-Allain RA Roudbaraki Morad M Tierny Dominique D Bonnal Jean-Louis JL Prevarskaya Natalia N Vanden Abeele Fabien F
iScience 20200612 7
Mitochondria are important cell death checkpoints, and mitochondrial Ca<sup>2+</sup> overload is considered as a potent apoptotic intrinsic pathway inducer. Here, we report that this Ca<sup>2+</sup> apoptosis link is largely ineffective in inducing cell-death just by itself and required a concomitant inhibition of autophagy to counteract its pro-survival action. In such condition, an acute mitochondrial stress revealed by a DRP1-mediated mitochondrial dynamic remodeling is observed concomitantly ...[more]
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