Dataset Information

Dynamic association between AT(N) profile and cognition mediated by cortical thickness in Alzheimer's continuum.

ABSTRACT:

Background

The recently-proposed National Institute on Aging and Alzheimer's Association research framework organizes Alzheimer's disease (AD) biomarkers based on amyloid/tau/neurodegeneration (AT(N)). This study investigated the mediating effect of structural change in brain MRI on changes in cognitive function according to initial AT(N) profiles.

Methods

We included 576 subjects (cognitively unimpaired (N = 136), mild cognitive impairment (N = 294), dementia (N = 146)) from the Alzheimer's disease Neuroimaging Initiative study. The parallel-process latent growth curve model was applied to test the mediational effect of cortical thickness growth trajectory between the initial AT(N) profiles and cognitive growth trajectory.

Results

In Alzheimer's continuum, only the A + T + (N)+ profile showed a mediational effect of the cortical thickness growth trajectory. A + T - (N)- was not sufficient to induce direct or indirect effects on cognitive dysfunction, and A + T + (N)- showed a significant direct path from an altered cortical thickness to cognitive decline.

Conclusion

The sequential effect between changes in brain MRI and cognition varied by baseline AT(N) profile, suggesting the dynamic changes in the relationships among biomarkers in the current cascade model.

SUBMITTER: Jang JW

PROVIDER: S-EPMC7322096 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Publications

Dynamic association between AT(N) profile and cognition mediated by cortical thickness in Alzheimer's continuum.

Jang Jae-Won JW Kim Yeshin Y Kim Seongheon S Park Sang Won SW Kwon Sung Ok SO Park Young Ho YH Lim Jae-Sung JS Youn Young Chul YC Hun Kim Sung S Kim SangYun S

NeuroImage. Clinical 20200526

<h4>Background</h4>The recently-proposed National Institute on Aging and Alzheimer's Association research framework organizes Alzheimer's disease (AD) biomarkers based on amyloid/tau/neurodegeneration (AT(N)). This study investigated the mediating effect of structural change in brain MRI on changes in cognitive function according to initial AT(N) profiles.<h4>Methods</h4>We included 576 subjects (cognitively unimpaired (N = 136), mild cognitive impairment (N = 294), dementia (N = 146)) from the ...[more]

PMID: 32590333

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Dataset Information

Dynamic association between AT(N) profile and cognition mediated by cortical thickness in Alzheimer's continuum.

Background

Methods

Results

Conclusion

Publications

Dynamic association between AT(N) profile and cognition mediated by cortical thickness in Alzheimer's continuum.

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