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Changes in pulmonary oxygen content are detectable with laser absorption spectroscopy: proof of concept in newborn piglets.

ABSTRACT: BACKGROUND:Using an optical method based on tunable diode laser absorption spectroscopy, we previously assessed oxygen (O2) and water vapor (H2O) content in a tissue phantom of the preterm infant lung. Here we applied this method on newborn piglets with induced lung complications. METHODS:Five mechanically ventilated piglets were subjected to stepwise increased and decreased fraction of inspired oxygen (FiO2), to atelectasis using a balloon catheter in the right bronchus, and to pneumothorax by injecting air in the pleural cavity. Two diode lasers (764?nm for O2 gas absorption and 820?nm for H2O absorption) were combined in a probe delivering light either externally, on the skin, or internally, through the esophagus. The detector probe was placed dermally. RESULTS:Calculated O2 concentrations increased from 20% (IQR 17-23%) when ventilated with room air to 97% (88-108%) at FiO2 1.0. H2O was only detectable with the internal light source. Specific light absorption and transmission patterns were identified in response to atelectasis and pneumothorax, respectively. CONCLUSIONS:The optical method detected FiO2 variations and discriminated the two induced lung pathologies, providing a rationale for further development into a minimally invasive device for real-time monitoring gas changes in the lungs of sick newborn infants. IMPACT:Optical spectroscopy can detect pulmonary complications in an animal model. Oxygen concentrations can be evaluated in the lungs. Presents a novel minimally invasive method to detect lung oxygenation and complications. Potential to be developed into a lung monitoring method in newborn infants. Potential for bed-side detection of pulmonary complications in newborn infants.

SUBMITTER: Svanberg EK

PROVIDER: S-EPMC7322222 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Changes in pulmonary oxygen content are detectable with laser absorption spectroscopy: proof of concept in newborn piglets.

Svanberg Emilie Krite EK Larsson Jim J Rasmussen Martin M Larsson Marcus M Leander Dennis D Bergsten Sara S Bood Joakim J Greisen Gorm G Fellman Vineta V

Pediatric research 20200613 4

<h4>Background</h4>Using an optical method based on tunable diode laser absorption spectroscopy, we previously assessed oxygen (O<sub>2</sub>) and water vapor (H<sub>2</sub>O) content in a tissue phantom of the preterm infant lung. Here we applied this method on newborn piglets with induced lung complications.<h4>Methods</h4>Five mechanically ventilated piglets were subjected to stepwise increased and decreased fraction of inspired oxygen (FiO<sub>2</sub>), to atelectasis using a balloon cathete ...[more]

PMID: 32534453

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Project description:Oxygen enriched air may increase oxygen pressure in brain tissue and have biochemical effects even in subjects without lung disease. Consistently, several studies demonstrated that normobaric oxygen treatment has clinical benefits in some neurological conditions. This study examined the efficacy of normobaric oxygen treatment in subjects with depression. In a randomized, double-blind trial, 55 participants aged 18-65 years with mild to moderate depression (had a Hamilton Rating Scale for Depression [HRSD] score of ≥ 8) were recruited to the study from the Southern district in Israel. Participants underwent a psychiatric inclusion assessment at baseline and then were randomly assigned to either normobaric oxygen treatment of 35% fraction of inspired oxygen or 21% fraction of inspired oxygen (room air) through a nasal tube, for 4 weeks, during the night. Evaluations were performed at baseline, 2 and 4 weeks after commencement of study interventions, using the following tools: HRSD; Clinical Global Impression (CGI) questionnaire; World Health Organization-5 questionnaire for the estimation of Quality of Life (WHO-5-QOL); Sense of Coherence (SOC) 13-item questionnaire; and, Sheehan Disability Scale (SDS). A multivariate regression analysis showed that the mean ± standard deviation [SD] changes in the HRSD scores from baseline to week four were - 4.2 ± 0.3 points in the oxygen-treated group and - 0.7 ± 0.6 in the control group, for a between-group difference of 3.5 points (95% confidence interval [CI] - 5.95 to - 1.0; P = 0.007). Similarly, at week four there was a between-group difference of 0.71 points in the CGI score (95% CI - 1.00 to - 0.29; P = 0.001). On the other hand, the analysis revealed that there were no significant differences in WHO-5-QOL, SOC-13 or SDS scores between the groups. This study showed a significant beneficial effect of oxygen treatment on some symptoms of depression.Trial registration: NCT02149563 (29/05/2014).

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Changes in pulmonary oxygen content are detectable with laser absorption spectroscopy: proof of concept in newborn piglets.

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Changes in pulmonary oxygen content are detectable with laser absorption spectroscopy: proof of concept in newborn piglets.

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