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Effect of Vitamin D Levels on Bone Remodeling in Healthy Women.

ABSTRACT: BackgroundVitamin D deficiency is prevalent among Indian women. Subclinical vitamin D deficiency is a significant risk factor for osteopenia and fractures. However, its effect on bone metabolism and bone mineral density (BMD) is still debatable.ObjectivesThis study aimed to determine relationships of the vitamin D status with bone turnover markers, carboxy-terminal telopeptide of type-I collagen (CTX), N-terminal propeptide of type I procollagen (PINP), and BMD in healthy Indian women.MethodsIn this cross-sectional study, we determined serum levels of 25-hydroxy vitamin D (25(OH)D), parathyroid hormone, serum CTX, and PINP using commercial ELISA kits in 310 healthy Indian women aged 25 - 65 years who underwent BMD measurements with DXA scan.ResultsThe prevalence of vitamin D deficiency was 53.87% and vitamin D insufficiency 31.29%. A direct correlation of BMD with vitamin D levels was not observed. PINP negatively correlated with vitamin D in both premenopausal (Spearman’s r = -0.169, P < 0.05) and postmenopausal (Spearman’s r = -0.241, P < 0.05) women. However, CTX positively correlated with vitamin D in both premenopausal (Spearman’s r = 0.228, P < 0.01) and postmenopausal (Spearman’s r = 0.244, P < 0.05) women.ConclusionsVitamin D deficiency is more prevalent in premenopausal women than in postmenopausal ones. Although vitamin D does not show any association with BMD, it affects bone remodeling, which is reflected by changes in the bone formation marker PINP and the bone resorption marker CTX.

SUBMITTER: Nair S

PROVIDER: S-EPMC7322670 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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