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Improved Outcomes With High-dose Isoniazid in Multidrug-resistant Tuberculosis Treatment in Haiti.

ABSTRACT: We report outcomes for a cohort of patients with multidrug-resistant tuberculosis who received high-dose isoniazid in Haiti. Patients who received high-dose isoniazid had a faster time to culture conversion and higher odds of successful outcome, despite high-level isoniazid resistance. This suggests high-dose isoniazid may have effectiveness even with phenotypic resistance.

SUBMITTER: Walsh KF 

PROVIDER: S-EPMC7322692 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Improved Outcomes With High-dose Isoniazid in Multidrug-resistant Tuberculosis Treatment in Haiti.

Walsh Kathleen F KF   Vilbrun Stalz Charles SC   Souroutzidis Ariadne A   Delva Sobieskye S   Joissaint Guy G   Mathurin Laurent L   Ocheretina Oksana O   Cremieux Pierre P   Pape Jean William JW   Koenig Serena P SP  

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20190801 4

We report outcomes for a cohort of patients with multidrug-resistant tuberculosis who received high-dose isoniazid in Haiti. Patients who received high-dose isoniazid had a faster time to culture conversion and higher odds of successful outcome, despite high-level isoniazid resistance. This suggests high-dose isoniazid may have effectiveness even with phenotypic resistance. ...[more]

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