Ontology highlight
ABSTRACT:
SUBMITTER: Fernandez-Santiago R
PROVIDER: S-EPMC7322732 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Fernández-Santiago Rubén R Martín-Flores Núria N Antonelli Francesca F Cerquera Catalina C Moreno Verónica V Bandres-Ciga Sara S Manduchi Elisabetta E Tolosa Eduard E Singleton Andrew B AB Moore Jason H JH Martí María-Josep MJ Ezquerra Mario M Malagelada Cristina C
Movement disorders : official journal of the Movement Disorder Society 20190624 9
<h4>Background</h4>Single nucleotide polymorphisms (SNPs) in the α-synuclein (SNCA) gene are associated with differential risk and age at onset (AAO) of both idiopathic and Leucine-rich repeat kinase 2 (LRRK2)-associated Parkinson's disease (PD). Yet potential combinatory or synergistic effects among several modulatory SNPs for PD risk or AAO remain largely underexplored.<h4>Objectives</h4>The mechanistic target of rapamycin (mTOR) signaling pathway is functionally impaired in PD. Here we explor ...[more]