Ontology highlight
ABSTRACT:
SUBMITTER: Ising C
PROVIDER: S-EPMC7324015 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Ising Christina C Venegas Carmen C Zhang Shuangshuang S Scheiblich Hannah H Schmidt Susanne V SV Vieira-Saecker Ana A Schwartz Stephanie S Albasset Shadi S McManus Róisín M RM Tejera Dario D Griep Angelika A Santarelli Francesco F Brosseron Frederic F Opitz Sabine S Stunden James J Merten Maximilian M Kayed Rakez R Golenbock Douglas T DT Blum David D Latz Eicke E Buée Luc L Heneka Michael T MT
Nature 20191120 7784
Alzheimer's disease is characterized by the accumulation of amyloid-beta in plaques, aggregation of hyperphosphorylated tau in neurofibrillary tangles and neuroinflammation, together resulting in neurodegeneration and cognitive decline<sup>1</sup>. The NLRP3 inflammasome assembles inside of microglia on activation, leading to increased cleavage and activity of caspase-1 and downstream interleukin-1β release<sup>2</sup>. Although the NLRP3 inflammasome has been shown to be essential for the devel ...[more]