Ontology highlight
ABSTRACT:
SUBMITTER: Kaji DA
PROVIDER: S-EPMC7324157 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Kaji Deepak A DA Howell Kristen L KL Balic Zerina Z Hubmacher Dirk D Huang Alice H AH
eLife 20200605
Tendon injuries are common with poor healing potential. The paucity of therapies for tendon injuries is due to our limited understanding of the cells and molecular pathways that drive tendon regeneration. Using a mouse model of neonatal tendon regeneration, we identified TGFβ signaling as a major molecular pathway that drives neonatal tendon regeneration. Through targeted gene deletion, small molecule inhibition, and lineage tracing, we elucidated TGFβ-dependent and TGFβ-independent mechanisms u ...[more]