Ontology highlight
ABSTRACT:
SUBMITTER: Wang K
PROVIDER: S-EPMC7324182 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Wang Kaiyuan K Gu Yun Y Liao Yihan Y Bang Sangsu S Donnelly Christopher R CR Chen Ouyang O Tao Xueshu X Mirando Anthony J AJ Hilton Matthew J MJ Ji Ru-Rong RR
The Journal of clinical investigation 20200701 7
Emerging immune therapy, such as with the anti-programmed cell death-1 (anti-PD-1) monoclonal antibody nivolumab, has shown efficacy in tumor suppression. Patients with terminal cancer suffer from cancer pain as a result of bone metastasis and bone destruction, but how PD-1 blockade affects bone cancer pain remains unknown. Here, we report that mice lacking Pdcd1 (Pd1-/-) demonstrated remarkable protection against bone destruction induced by femoral inoculation of Lewis lung cancer cells. Compar ...[more]