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Lung cancer prediction in Lambert-Eaton myasthenic syndrome in a prospective cohort.


ABSTRACT: To evaluate the Dutch-English Lambert-Eaton Myasthenic Syndrome (LEMS) Tumour Association Prediction (DELTA-P) score in a prospective cohort of patients with newly diagnosed LEMS to assess the clinical validity of this tool in a real-world setting. Clinical features from 87 patients with LEMS, occurring within three months from disease onset, were collated to produce a DELTA-P score for each patient. Lung cancer was detected in 44/87 (51%) LEMS patients. Weight loss???5%, tobacco use at LEMS onset and age at onset???50 years were independent predictors for the development of small-cell lung cancer (SCLC) in LEMS patients in multivariable analysis. Median DELTA-P scores were significantly higher in SCLC-LEMS patients (3.5, 95% CI 3 to 4) compared to non-tumour-LEMS (2, 95% CI 1 to 2) (P?

SUBMITTER: Maddison P 

PROVIDER: S-EPMC7324357 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Lung cancer prediction in Lambert-Eaton myasthenic syndrome in a prospective cohort.

Maddison Paul P   Lipka Alexander F AF   Gozzard Paul P   Sadalage Girija G   Ambrose Philip A PA   Lang Bethan B   Verschuuren Jan J JJ  

Scientific reports 20200629 1


To evaluate the Dutch-English Lambert-Eaton Myasthenic Syndrome (LEMS) Tumour Association Prediction (DELTA-P) score in a prospective cohort of patients with newly diagnosed LEMS to assess the clinical validity of this tool in a real-world setting. Clinical features from 87 patients with LEMS, occurring within three months from disease onset, were collated to produce a DELTA-P score for each patient. Lung cancer was detected in 44/87 (51%) LEMS patients. Weight loss ≥ 5%, tobacco use at LEMS ons  ...[more]

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