Ontology highlight
ABSTRACT:
SUBMITTER: Hsu KC
PROVIDER: S-EPMC7324578 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Scientific reports 20200629 1
The immune system works in conjunction with inflammation. Excessive inflammation underlies various human diseases, such as asthma, diabetes and heart disease. Previous studies found that 5-lipoxygenase (5-LOX) plays a crucial role in metabolizing arachidonic acid into inflammatory mediators and is a potential therapeutic target. In this study, we performed an in silico approach to establish a site-moiety map (SiMMap) to screen for new 5-LOX inhibitors. The map is composed of several anchors that ...[more]