Validation of four-dimensional flow cardiovascular magnetic resonance for aortic stenosis assessment.

ABSTRACT: The management of patients with aortic stenosis (AS) crucially depends on accurate diagnosis. The main aim of this study were to validate the four-dimensional flow (4D flow) cardiovascular magnetic resonance (CMR) methods for AS assessment. Eighteen patients with clinically severe AS were recruited. All patients had pre-valve intervention 6MWT, echocardiography and CMR with 4D flow. Of these, ten patients had a surgical valve replacement, and eight patients had successful transcatheter aortic valve implantation (TAVI). TAVI patients had invasive pressure gradient assessments. A repeat assessment was performed at 3-4 months to assess the remodelling response. The peak pressure gradient by 4D flow was comparable to an invasive pressure gradient (54?±?26?mmHG vs 50?±?34?mmHg, P?=?0.67). However, Doppler yielded significantly higher pressure gradient compared to invasive assessment (61?±?32?mmHG vs 50?±?34?mmHg, P?=?0.0002). 6MWT was associated with 4D flow CMR derived pressure gradient (r?=?-0.45, P?=?0.01) and EOA (r?=?0.54, P?

SUBMITTER: Archer GT 

PROVIDER: S-EPMC7324609 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature