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Overexpression of human epidermal growth factor receptor 2 in canine primary lung cancer.

ABSTRACT: Human epidermal growth factor receptor 2 (HER2) overexpression has been reported in various human cancers. HER2-targeted therapies showed clinical responses in humans with HER2-positive tumors. The incidence of canine primary lung cancer (cPLC) is increasing, but there are no effective systemic therapies for dogs with late-stage cPLC. HER2-targeted therapy could be an option for cPLC, but HER2 expression in cPLC remains unknown. We evaluated HER2 expression in cPLC. Immunohistochemical analysis revealed that 3 samples (19%) scored 3+; 8 (50%), 2+; 5 (31%); and 1+ and 0 (0%), 0. Of the cPLC tissues, 69% were HER2 positive (scored ?2+). These data would lead to further evaluation of the role of HER2 in cPLC as a mechanism of malignancy and therapeutic target.

SUBMITTER: Yoshimoto S

PROVIDER: S-EPMC7324825 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Overexpression of human epidermal growth factor receptor 2 in canine primary lung cancer.

Yoshimoto Sho S Kato Daiki D Kamoto Satoshi S Yamamoto Kie K Tsuboi Masaya M Shinada Masahiro M Ikeda Namiko N Tanaka Yuiko Y Yoshitake Ryohei R Eto Shotaro S Saeki Kohei K Chambers James J Hashimoto Yuko Y Uchida Kazuyuki K Nishimura Ryohei R Nakagawa Takayuki T

The Journal of veterinary medical science 20200403 6

Human epidermal growth factor receptor 2 (HER2) overexpression has been reported in various human cancers. HER2-targeted therapies showed clinical responses in humans with HER2-positive tumors. The incidence of canine primary lung cancer (cPLC) is increasing, but there are no effective systemic therapies for dogs with late-stage cPLC. HER2-targeted therapy could be an option for cPLC, but HER2 expression in cPLC remains unknown. We evaluated HER2 expression in cPLC. Immunohistochemical analysis ...[more]

PMID: 32249253

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