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Association of Low to Moderate Alcohol Drinking With Cognitive Functions From Middle to Older Age Among US Adults.

ABSTRACT: Importance:Studies examining the association of low to moderate drinking with various cognitive functions have yielded mixed findings. Objective:To investigate whether associations exist between low to moderate alcohol drinking and cognitive function trajectories or rates of change in cognitive function from middle age to older age among US adults. Design, Setting, and Participants:A prospective cohort study of participants drawn from the Health and Retirement Study (HRS), a nationally representative sample of US adults, with mean (SD) follow-up of 9.1 (3.1) years. In total, 19?887 participants who had their cognitive functions measured in the HRS starting in 1996 through 2008 and who had participated in at least 3 biennial surveys were included. The data analysis was conducted from June to November 2019. Exposures:Alcohol consumption and aging. Main Outcomes and Measures:Trajectories and annual rates of change for the cognitive domains of mental status, word recall, and vocabulary and for the total cognitive score, which was the sum of the mental status and word recall scores. Participants were clustered into 2 cognitive function trajectories for each cognition measure assessed based on their scores at baseline and through at least 3 biennial surveys: a consistently low trajectory (representing low cognitive scores throughout the study period) and a consistently high trajectory (representing high cognitive scores throughout the study period). Results:The mean (SD) age of 19?887 participants was 61.8 (10.2) years, and the majority of the HRS participants were women (11?943 [60.1%]) and of white race/ethnicity (16?950 [85.2%]). Low to moderate drinking (<8 drinks per week for women and <15 drinks per week for men) was significantly associated with a consistently high cognitive function trajectory and a lower rate of cognitive decline. Compared with never drinkers, low to moderate drinkers were less likely to have a consistently low trajectory for total cognitive function (odds ratio [OR], 0.66; 95% CI, 0.59-0.74), mental status (OR, 0.71; 95% CI, 0.63-0.81), word recall (OR, 0.74; 95% CI, 0.69-0.80), and vocabulary (OR, 0.64; 95% CI, 0.56-0.74) (all P?

SUBMITTER: Zhang R

PROVIDER: S-EPMC7324954 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Association of Low to Moderate Alcohol Drinking With Cognitive Functions From Middle to Older Age Among US Adults.

Zhang Ruiyuan R Shen Luqi L Miles Toni T Shen Ye Y Cordero Jose J Qi Yanling Y Liang Lirong L Li Changwei C

JAMA network open 20200601 6

<h4>Importance</h4>Studies examining the association of low to moderate drinking with various cognitive functions have yielded mixed findings.<h4>Objective</h4>To investigate whether associations exist between low to moderate alcohol drinking and cognitive function trajectories or rates of change in cognitive function from middle age to older age among US adults.<h4>Design, setting, and participants</h4>A prospective cohort study of participants drawn from the Health and Retirement Study (HRS), ...[more]

PMID: 32597992

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Project description:BackgroundBehavioral economic theory predicts that low access to environmental reward is a risk factor for alcohol use disorder (AUD). The Substance-Free Activity Session (SFAS) is a behavioral economic supplement to standard brief alcohol interventions that attempts to increase environmental reward and may therefore have beneficial effects, particularly for individuals with low levels of environmental reward.MethodsParticipants were 393 college students who reported at least 2 heavy-drinking episodes in the past month. Participants were randomly assigned to 1 of 3 conditions following a baseline assessment: a standard alcohol-focused brief motivational intervention plus relaxation training session (BMI + RT), BMI plus Substance-Free Activity Session (BMI + SFAS), or an assessment-only control condition (AO). In a secondary analysis of the data from this study, we used person-centered statistical techniques to describe trajectories of alcohol severity and environmental reward over a 16-month follow-up and examined whether environmental reward levels moderated the effectiveness of the interventions.ResultsPiecewise growth mixture modeling identified 2 trajectories of reward availability: low increasing (LR; n = 120) and high stable (HR; n = 273). Depressive symptoms, cannabis use, sensation seeking, and low life satisfaction were associated with a greater probability of classification in the LR trajectory. Alcohol severity was greater in the LR trajectory than the HR trajectory. For students in the LR trajectory, at 1, 6, and 12 months, BMI + SFAS led to greater increases in reward availability and reduced levels of alcohol severity compared with the BMI + RT and AO conditions and at 16 months compared with AO.ConclusionsYoung adults with low levels of environmental reward are at heightened risk for greater alcohol severity and may show greater benefit from brief alcohol interventions that focus on increasing substance-free reward than individuals who are not deficient in reward availability.

Dataset Information

Association of Low to Moderate Alcohol Drinking With Cognitive Functions From Middle to Older Age Among US Adults.

Publications

Association of Low to Moderate Alcohol Drinking With Cognitive Functions From Middle to Older Age Among US Adults.

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