Ontology highlight
ABSTRACT:
SUBMITTER: Huang X
PROVIDER: S-EPMC7325042 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Huang Xing X Zhang Xiaozhen X Li Enliang E Zhang Gang G Wang Xun X Tang Tianyu T Bai Xueli X Liang Tingbo T
Journal of hematology & oncology 20200629 1
VISTA (V-domain immunoglobulin suppressor of T cell activation) is a well-established immune regulatory receptor. However, pre-clinical investigations indicated more complicated influences of VISTA on cancer immunity than previously recognized. Here, we review the current knowledge on the therapeutic phenotypes and molecular mechanisms that underlie the contradictory roles of VISTA in checking anti-cancer immune responses. Furthermore, we highlight the potential indeterminacy of VISTA-targeted s ...[more]