Ontology highlight
ABSTRACT:
SUBMITTER: Michels KR
PROVIDER: S-EPMC7325330 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
The Journal of infectious diseases 20190801 7
Sepsis from Escherichia coli expressing the K1 antigen is a leading cause of death in neonates. In a murine model, E. coli K1 grew rapidly in the peritoneal cavity of neonatal mice, causing fatal disease. In contrast, adult mice cleared the infection. Neonatal mice mounted a rapid and equivalent antimicrobial immune response compared to adult mice. Interestingly, peritoneal fluid from neonatal mice contained significantly more total iron than that of adult mice, which was sufficient to support e ...[more]