Ontology highlight
ABSTRACT: Purpose
Although the incidence rate of epithelial ovarian cancer (EOC) is somewhat lower in African American (AA) than white women, survival is worse. The Ovarian Cancer in Women of African Ancestry (OCWAA) consortium will overcome small, study-specific sample sizes to better understand racial differences in EOC risk and outcomes.Methods
We harmonized risk factors and prognostic characteristics from eight U.S.Studies
the North Carolina Ovarian Cancer Study (NCOCS), the Los Angeles County Ovarian Cancer Study (LACOCS), the African American Cancer Epidemiology Study (AACES), the Cook County Case-Control Study (CCCCS), the Black Women's Health Study (BWHS), the Women's Health Initiative (WHI), the Multiethnic Cohort Study (MEC), and the Southern Community Cohort Study (SCCS).Results
Determinants of disparities for risk and survival in 1,146 AA EOC cases and 2,922 AA controls will be compared to 3,368 white EOC cases and 10,270 white controls. Analyses include estimation of population-attributable risk percent (PAR%) by race.Conclusion
OCWAA is uniquely positioned to study the epidemiology of EOC in AA women compared with white women to address disparities. Studies of EOC have been underpowered to address factors that may explain AA-white differences in the incidence and survival. OCWAA promises to provide novel insight into disparities in ovarian cancer.
SUBMITTER: Schildkraut JM
PROVIDER: S-EPMC7325484 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Schildkraut Joellen M JM Peres Lauren C LC Bethea Traci N TN Camacho Fabian F Chyn Deanna D Cloyd Emily K EK Bandera Elisa V EV Beeghly-Fadiel Alicia A Lipworth Loren L Joslin Charlotte E CE Davis Faith G FG Moorman Patricia G PG Myers Evan E Ochs-Balcom Heather M HM Setiawan Veronica Wendy VW Pike Malcolm C MC Wu Anna H AH Rosenberg Lynn L
Cancer causes & control : CCC 20190624 9
<h4>Purpose</h4>Although the incidence rate of epithelial ovarian cancer (EOC) is somewhat lower in African American (AA) than white women, survival is worse. The Ovarian Cancer in Women of African Ancestry (OCWAA) consortium will overcome small, study-specific sample sizes to better understand racial differences in EOC risk and outcomes.<h4>Methods</h4>We harmonized risk factors and prognostic characteristics from eight U.S.<h4>Studies</h4>the North Carolina Ovarian Cancer Study (NCOCS), the Lo ...[more]