Unknown

Dataset Information

0

Impact of Water Quality, Sanitation, Handwashing, and Nutritional Interventions on Enteric Infections in Rural Zimbabwe: The Sanitation Hygiene Infant Nutrition Efficacy (SHINE) Trial.


ABSTRACT:

Background

We assessed the impact of water, sanitation, and hygiene (WASH) and infant and young child feeding (IYCF) interventions on enteric infections in the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial in rural Zimbabwe.

Methods

We tested stool samples collected at 1, 3, 6, and 12 months of age and during diarrhea using quantitative molecular diagnostics for 29 pathogens. We estimated the effects of the WASH, IYCF, and combined WASH + IYCF interventions on individual enteropathogen prevalence and quantity, total numbers of pathogens detected, and incidence of pathogen-attributable diarrhea.

Results

WASH interventions decreased the number of parasites detected (difference in number compared to non-WASH arms, -0.07 [95% confidence interval, -.14 to -.02]), but had no statistically significant effects on bacteria, viruses, or the prevalence and quantity of individual enteropathogens after accounting for multiple comparisons. IYCF interventions had no significant effects on individual or total enteropathogens. Neither intervention had significant effects on pathogen-attributable diarrhea.

Conclusions

The WASH interventions implemented in SHINE (improved pit latrine, hand-washing stations, liquid soap, point-of-use water chlorination, and clean play space) did not prevent enteric infections. Transformative WASH interventions are needed that are more efficacious in interrupting fecal-oral microbial transmission in children living in highly contaminated environments.

SUBMITTER: Rogawski McQuade ET 

PROVIDER: S-EPMC7325799 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC6023145 | biostudies-literature
| S-EPMC4657589 | biostudies-literature
| S-EPMC6206106 | biostudies-literature
| S-EPMC7046282 | biostudies-literature
2024-03-08 | GSE261098 | GEO
| S-EPMC7205402 | biostudies-literature
| S-EPMC5675593 | biostudies-literature
| S-EPMC5809717 | biostudies-literature
| S-EPMC5809718 | biostudies-literature
| S-EPMC5859215 | biostudies-literature