Ontology highlight
ABSTRACT:
SUBMITTER: Aykul S
PROVIDER: S-EPMC7326492 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
eLife 20200609
Activin A functions in BMP signaling in two ways: it either engages ACVR1B to activate Smad2/3 signaling or binds ACVR1 to form a non-signaling complex (NSC). Although the former property has been studied extensively, the roles of the NSC remain unexplored. The genetic disorder fibrodysplasia ossificans progressiva (FOP) provides a unique window into ACVR1/Activin A signaling because in that disease Activin can either signal through FOP-mutant ACVR1 or form NSCs with wild-type ACVR1. To explore ...[more]