Assessment of neonatal EEG background and neurodevelopment in full-term small for their gestational age infants.

ABSTRACT:

Background

Delayed brain function development in small-gestational-age (SGA) infants has been reported. We aimed to quantify rates of immature neonatal EEG patterns and their association with neurodevelopment in SGA full-term neonates.

Methods

Using a cohort design, 50 SGA (birthweight <10th percentile) and 44 appropriate-gestational-age (AGA) term neonates underwent continuous video-EEG recordings lasting >3?h. Seventy-three of them were assessed at 2-years-old using Bayley-III-Scales. For EEG analysis, several segments of discontinuous/alternating EEG tracings were selected.

Main outcomes measured

(1) Visual analysis (patterns of EEG maturity); (2) Power spectrum in ?, ?, ? and ? frequency bands; and (3) scores in motor, cognitive and language development.

Results

(1) SGA infants, compared to AGA, showed: (a) higher percentages of discontinuous EEG, both asynchrony and interhemispheric asymmetry, and bursts with delta-brushes, longer interburst-interval duration and more transients/hour; (b) lower relative power spectrum in ? and higher in ?; and (c) lower scores on motor, language and cognitive neurodevelopment. (2) Asymmetry >5%, interburst-interval >5?s, discontinuity >11%, and bursts with delta-brushes >11% were associated with lower scores on Bayley-III.

Conclusions

In this prospective study, SGA full-term neonates showed high rates of immature EEG patterns. Low-birthweight and immaturity EEG were both correlated with low development scores.

SUBMITTER: Castro Conde JR 

PROVIDER: S-EPMC7326702 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature