Experimental Variables that Affect Human Hepatocyte AAV Transduction in Liver Chimeric Mice.
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ABSTRACT: Liver chimeric mice are widely used to model human hepatocyte susceptibility to adeno-associated virus (AAV) gene vector transduction with inconsistent finding between laboratories. Zou et al. quantify to what extent three experimental conditions—namely, mouse liver injury, human donor variability, and AAV doses—affect human hepatocyte transduction in chimeric mice.
SUBMITTER: Zou C
PROVIDER: S-EPMC7326722 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
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