Ontology highlight
ABSTRACT:
SUBMITTER: Ferrara M
PROVIDER: S-EPMC7326777 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frontiers in immunology 20200624
Acute inflammation is a complex biological response of tissues to harmful stimuli, such as pathogens or cell damage, and is essential for immune defense and proper healing. However, unresolved inflammation can lead to chronic disorders, including cancer and fibrosis. The High Mobility Group Box 1 (HMGB1) protein is a Damage-Associated Molecular Pattern (DAMP) molecule that orchestrates key events in inflammation by switching among mutually exclusive redox states. Fully reduced HMGB1 (frHMGB1) su ...[more]