Ontology highlight
ABSTRACT:
SUBMITTER: Yang K
PROVIDER: S-EPMC7326958 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Yang Kang K Du Jianwei J Shi Dai D Ji Feng F Ji Yong Y Pan Junbo J Lv Fei F Zhang Yao Y Zhang Jie J
Cell death & disease 20200630 6
Malignant peripheral nerve sheath tumours (MPNSTs) are highly aggressive Schwann cell-derived sarcomas, and they are either associated with neurofibromatosis type 1 (NF1) or sporadic. Our previous study found that high mobility group protein A2 (HMGA2) regulates NF1-MPNST growth through Musashi-2 (MSI2); however, whether MSI2 regulates MPNST metastasis and what the mechanism is remain unclear. Here, we demonstrated that the protein caveolin-1 (CAV1) directly interacts with MSI2 in human NF1-MPNS ...[more]