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Prevalence of Sjogren's syndrome in the general adult population in Spain: estimating the proportion of undiagnosed cases.


ABSTRACT: To estimate the prevalence of Sjögren's syndrome (SS) in the adult Spanish population we performed a population-based multicenter cross-sectional study. Cases were defined by the American-European Consensus Group criteria proposed in 2002. A total of 4,916 subjects aged 20 years or over were included. The estimated prevalence of SS (including primary and secondary forms) in the adult population in Spain was 0.33% (95% CI 0.21-0.53). Extrapolating to the total population of the country aged ??20 years (around 37.7 million persons), there would be around 125,000 cases of SS in Spain. Considering only primary SS, the estimated prevalence was 0.25% (95% CI 0.15-0.43) or 1 person in 400. The prevalence of primary SS in Spain is comparable to that reported in other European studies with a similar design and diagnostic criteria. Based on these results, primary SS could not be considered a rare (orphan) disease. Only 50% of cases had already been diagnosed with SS prior EPISER 2016 study, confirming the existence of a non-negligible proportion of undiagnosed cases in the general population.

SUBMITTER: Narvaez J 

PROVIDER: S-EPMC7327007 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Prevalence of Sjögren's syndrome in the general adult population in Spain: estimating the proportion of undiagnosed cases.

Narváez Javier J   Sánchez-Fernández Simón Ángel SÁ   Seoane-Mato Daniel D   Díaz-González Federico F   Bustabad Sagrario S  

Scientific reports 20200630 1


To estimate the prevalence of Sjögren's syndrome (SS) in the adult Spanish population we performed a population-based multicenter cross-sectional study. Cases were defined by the American-European Consensus Group criteria proposed in 2002. A total of 4,916 subjects aged 20 years or over were included. The estimated prevalence of SS (including primary and secondary forms) in the adult population in Spain was 0.33% (95% CI 0.21-0.53). Extrapolating to the total population of the country aged ≥ 20   ...[more]

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