Dataset Information

Preliminary Indications That First Semester Students From Academic Households Exhibit Higher Hair Cortisol Concentrations Than Their Peers From Nonacademic Households.

ABSTRACT: Previous research has extensively addressed social disparity in education using certain aspects, including the stress differences between students from nonacademic families and those from academic families during the transition from secondary school to a university. However, this issue has not yet been fully understood; the current literature suggests contradictory predictions, and physiological indicators of stress have never been assessed. Therefore, we tested whether hair cortisol concentrations (HCCs) in first semester students from nonacademic families are different from those of first semester students from academic families during their first six weeks at university. We analyzed hair samples and parental educational background reports from 71 female first semester students at a university in Switzerland in two waves (n = 34 in the autumn of 2016 and n = 37 in the autumn of 2017). The HCCs were extracted from the hair using a well-established protocol. The analyses revealed higher HCCs in the students from the academic families across the two cohorts. This difference could not be attributed to different control variables (e.g., age, migration background). These preliminary findings were in line with the sociological theory that an academic parental background is associated with pressure to avoid a drop in one's social status.

SUBMITTER: Bertrams A

PROVIDER: S-EPMC7327536 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Preliminary Indications That First Semester Students From Academic Households Exhibit Higher Hair Cortisol Concentrations Than Their Peers From Nonacademic Households.

Bertrams Alex A Minkley Nina N

Frontiers in psychiatry 20200624

Previous research has extensively addressed social disparity in education using certain aspects, including the stress differences between students from nonacademic families and those from academic families during the transition from secondary school to a university. However, this issue has not yet been fully understood; the current literature suggests contradictory predictions, and physiological indicators of stress have never been assessed. Therefore, we tested whether hair cortisol concentrati ...[more]

PMID: 32670110

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Project description:Distal hair segments collected at delivery may allow for the assessment of maternal cortisol secretion in early pregnancy, an important time window for fetal development. Therefore, an investigation of the validity of distal hair cortisol concentrations is warranted. We examined the concordance between proximal and distal hair cortisol concentrations (HCC), both representing the first trimester of pregnancy. The study population was comprised of a random sample of 97 women participating in the Pregnancy Outcomes Maternal and Infant Study, a prospective cohort study of pregnant women attending prenatal clinics in Lima, Peru. Each participant provided two hair samples: once at enrollment [mean gestational age (GA) = 13.1 weeks] and again at full-term delivery (mean GA = 39.0 weeks). Hair segments reflecting the first trimester were: 3 cm hair segments closest to the scalp on the first hair sample (proximal) and 6-9 cm from the scalp on the second hair sample (distal). HCC was determined using Luminescence Immunoassay. A subset (N = 28) had both hair segments additionally analyzed using liquid chromatography tandem mass spectrometry (LC-MS/MS). HCC values were log-transformed (logHCC), and proximal-distal differences tested using paired sample t-tests. Concordance was evaluated within and across assay types. LogHCC, measured using immunoassay, in distal hair segments was lower compared to proximal hair segments (1.35 versus 1.64 respectively; p = .02). No difference was observed using LC-MS/MS (1.99 versus 1.83, respectively; p=.33). Proximal-distal concordance was low within assay (immunoassay: Pearson = 0.27 and κ = 0.10; LC-MS/MS: Pearson = 0.37 and κ = 0.07). High correlation was observed across assays for both distal (Pearson = 0.78, p < .001; κ = 0.64) and proximal segments (Pearson = 0.96, p < .001; κ = 0.75). In conclusion, distal first-trimester hair segments collected at delivery have lower absolute HCC compared to HCC in proximal first trimester hair segments collected in early pregnancy, and are poorly concordant with HCC in proximal segments. Findings may inform the design of future studies.

Project description:Background: Academic physicians, such as those affiliated with National Cancer Institute (NCI)-designated Comprehensive Cancer Centers, may have different practice patterns regarding the use of high-cost cancer drugs than nonacademic physicians.Materials and methods: For this cohort study, we linked cancer registry, administrative, and demographic data for patients with newly diagnosed cancer in North Carolina from 2004 to 2011. We selected cancer types with multiple U.S. Food and Drug Administration-approved, National Comprehensive Cancer Network-recommended treatment options and large differences in reimbursement between higher-priced and lower-priced options (stage IV colorectal, stage IV lung, and stage II-IV head-and-neck cancers). We assessed whether provider's practice setting-NCI-designated Comprehensive Cancer Center ("NCI") versus other location ("non-NCI")-was associated with use of higher-cost treatment options. We used inverse probability of exposure weighting to control for patient characteristics.Results: Of 800 eligible patients, 79.6% were treated in non-NCI settings. Patients treated in non-NCI settings were more likely to receive high-cost treatment than patients treated in NCI settings (36.0% vs. 23.2%), with an unadjusted prevalence difference of 12.7% (95% confidence interval [CI], 5.1%-20.0%). After controlling for potential confounding factors, non-NCI patients remained more likely to receive high-cost treatment, although the strength of association was attenuated (adjusted prevalence difference, 9.6%; 95% CI -0.1%-18.7%). Exploratory analyses suggested potential heterogeneity across cancer type and insurance status.Conclusion: Use of higher-cost cancer treatments may be more common in non-NCI than NCI settings. This may reflect differential implementation of clinical evidence, local practice variation, or possibly a response to the reimbursement incentives presented by chemotherapy billing.Implications for practice: Oncology care delivery and practice patterns may vary between care settings. By comparing otherwise similar patients treated in National Cancer Institute (NCI)-designated Comprehensive Cancer Centers with those treated elsewhere, this study suggests that patients may be more likely to receive treatment with certain expensive cancer drugs if treated in the non-NCI setting. These practice differences may result in differences in patient costs and outcomes as a result of where they receive treatment.

Dataset Information

Preliminary Indications That First Semester Students From Academic Households Exhibit Higher Hair Cortisol Concentrations Than Their Peers From Nonacademic Households.

Publications

Preliminary Indications That First Semester Students From Academic Households Exhibit Higher Hair Cortisol Concentrations Than Their Peers From Nonacademic Households.

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