Ontology highlight
ABSTRACT:
SUBMITTER: Drufva EE
PROVIDER: S-EPMC7327777 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Drufva Erin E EE Hix Elijah G EG Bailey Constance B CB
Synthetic and systems biotechnology 20200513 2
Modular polyketide synthases (PKSs) are a multidomain megasynthase class of biosynthetic enzymes that have great promise for the development of new compounds, from new pharmaceuticals to high value commodity and specialty chemicals. Their colinear biosynthetic logic has been viewed as a promising platform for synthetic biology for decades. Due to this colinearity, domain swapping has long been used as a strategy to introduce molecular diversity. However, domain swapping often fails because it pe ...[more]