Ontology highlight
ABSTRACT:
SUBMITTER: Nakai S
PROVIDER: S-EPMC7327905 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Nakai Shiho S Oyabu Mamoru M Hatazawa Yukino Y Akashi Shiori S Kitamura Tadahiro T Miura Shinji S Kamei Yasutomi Y
FEBS open bio 20200701 7
Peroxisome proliferator-activated receptor-gamma coactivator-1β (PGC-1β) is a transcriptional regulator whose increased expression activates energy expenditure-related genes in skeletal muscles. However, how PGC-1β is regulated remains largely unclear. Here, we show that PGC-1β gene expression is negatively correlated with the expression of a transcription factor, forkhead box protein O1 (FOXO1), whose expression is increased during muscle atrophy. In the skeletal muscles of FOXO1-overexpressing ...[more]