Asthma: An Untoward Consequence of Endurance Sports?
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ABSTRACT:
SUBMITTER: Bosse Y
PROVIDER: S-EPMC7328247 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:Sport performance is influenced by several factors, including genetic susceptibility. In the past years, specific single nucleotide polymorphisms have been associated to sport performance; however, these effects should be considered in multivariable prediction systems since they are related to a polygenic inheritance. The aim of this study was to design a genetic endurance prediction score (GES) of endurance performance and analyze its association with anthropometric, nutritional and sport efficiency variables in a cross-sectional study within fifteen male cyclists. A statistically significant positive relationship between GES and the VO2 maximum (P = 0.033), VO2 VT1 (P = 0.049) and VO2 VT2 (P < 0.001) was observed. Moreover, additional remarkable associations between genotype and the anthropometric, nutritional and sport performance variables, were achieved. In addition, an interesting link between the habit of consuming caffeinated beverages and the GES was observed. The outcomes of the present study indicate a potential use of this genetic prediction algorithm in the sports' field, which may facilitate the finding of genetically talented athletes, improve their training and food habits, as well as help in the improvement of physical conditions of amateurs.
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Project description:IntroductionBlood lactate concentration rises exponentially during graded exercise when muscles produce more lactate than the body can remove, and the blood lactate-related thresholds are parameters based on this curve used to evaluate performance level and help athletes optimize training. Many different concepts of describing such a threshold have been published. This study aims to compare concepts for their repeatability and predictive properties of endurance performance.MethodsForty-eight well-trained male cyclists aged 18-50 performed 5 maximal graded exercise tests each separated by two weeks. Blood lactate-related thresholds were calculated using eight different representative concepts. Repeatability of each concept was assessed using Cronbach's alpha and intra-subject CV and predictive value with 45 minute time trial tests and a road race to the top of Mont Ventoux was evaluated using Pearson correlations.ResultsRepeatability of all concepts was good to excellent (Cronbach's alpha of 0.89-0.96), intra-subject CVs were low with 3.4-8.1%. Predictive value for performance in the time trial tests and road race showed significant correlations ranging from 0.65-0.94 and 0.53-0.76, respectively.ConclusionAll evaluated concepts performed adequate, but there were differences between concepts. One concept had both the highest repeatability and the highest predictability of cycling performance, and is therefore recommended to be used: the Dmax modified method. As an easier to apply alternative, the lactate threshold with a fixed value of 4 mmol/L could be used as it performed almost as well.Trial registrationDutch Trial Registry NTR5643.
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Project description:A meta-analysis was performed with the aim of re-evaluating the role of the peroxisome proliferator activated receptor alpha (PPARA) gene intron 7 G/C polymorphism (rs4253778) in athletes' high ability in endurance sports.A meta-analysis of case control studies assessing the association between the G/C polymorphisms of the PPARA gene and endurance sports was conducted. The Cochrane Review Manager software was used to compare the genotype and allele frequencies between endurance athletes and controls to determine whether a genetic variant is more common in athletes than in the general population. Five studies, encompassing 760 endurance athletes and 1792 controls, fulfilled our inclusion criteria. The pooled odds ratio (and confidence intervals, CIs) for the G allele compared to the C allele was 1.65 (95% CI 1.39-1.96). The pooled OR for the GG genotype compared to the GC genotype was 1.79 (95% CI 1.44-2.22), and for the GG genotype compared to the CC genotype 2.37 (95% CI 1.40-3.99). There was no evidence of heterogeneity (I(2) =0%) or of publication bias. Athletes with high ability in endurance sports had a higher frequency of the GG genotype and G allele.
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Project description:Medium-intensity activities comprise the major proportion of many sorts of sports. The energy consumption of athletes has been a research emphasis for the purpose of improving both training efficiency and competition performance. However, the evidence based on large-scale gene screen has been rarely performed. This is a bioinformatic study revealing the key factors contributed to the metabolic difference between subjects with different endurance activity capacities. A dataset comprised of high- (HCR) and low-capacity running (LCR) rats was used. Differentially expressed genes (DEGs) were identified and analysed. The Gene Ontology (GO) and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment was obtained. The DEGs' protein-protein interaction (PPI) network was built, and the enriched terms of the PPI network were also analysed. Our findings showed that the GO terms were enriched in lipid metabolism-related terms. The KEGG signalling pathway analysis enriched in the ether lipid metabolism. Plb1, Acad1, Cd2bp2, and Pla2g7 were identified as the hub genes. This study provides a theoretical foundation showing lipid metabolism plays an important role in the performance of endurance activities. Plb1, Acad1, and Pla2g7 may be the key genes involved. The training plan and diet for athletes can be designed based on above results and expecting a better competitive performance.
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Project description:During the last few years, the numbers of competitors in endurance and ultra-endurance sports modalities have increased significantly. This type of competition is an extreme challenge for athletes. Therefore, they have an increased the risk of developing medical and nutritional problems. The aim of the work is to estimate the incidence of nutrition-related adverse outcomes in endurance and ultra-endurance sports, considering the variables that influence them. A critical review was carried out based on the PubMed database, by means of a search strategy based on keywords separated by Boolean connectors. For all the results obtained in a period from 2008 to 2019, a series of inclusion/exclusion criteria was applied to select only the studies that fitted the objective of the present study. Results and discussion: Of the 871 publications identified, 33 met the inclusion criteria. The adverse outcomes found included exercise-associated hyponatremia (EAH), heat stroke by exertion (EHS), gastrointestinal (GI) problems, dehydration, and hypothermia; the provision of misinformation to athletes about nutrient intake and hydration during competition was identified as the main cause. Conclusions: The main adverse outcomes in endurance and ultra-endurance sports modalities are EAH, GI inconveniences, and EHS. These problems can affect the performance and health status of the athlete during and post-competition. Several nutritional guidelines have been suggested that can prevent these adverse outcomes, and it is essential to individualize and adjust the nutritional intake and hydration status according to the characteristics of each competition.
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Project description:Orthorexia Nervosa (ON) is an eating disorder marked by an excessive control over the quality of the food eaten. Some groups present a higher prevalence of ON and people practicing sports seems to be a population at risk. The aim of this study is to assess the prevalence of ON in endurance athletes and to compare their prevalence with the ones recorded in the sedentary population and in athletes playing other sports. A cross-sectional survey was carried in Piedmont and Valle d'Aosta, among 549 participants in local sports events aged between 18 and 40 years old. The questionnaire assessed socio-demographic characteristics, physical activity, nutrition and diet, the ORTO-15 questionnaire and Eating Habits Questionnaire (EHQ). The sample was stratified according to the minutes of sport practiced in a week and the type of sport played. Crosstab chi-square analyses to determine group differences on categorical variables (e.g. gender), and ANOVAs or t tests to determine group differences on continuous variables were performed. When required, post hoc analyses were performed. Linear and logistic regressions were performed in order to investigate potential predictors of orthorexia. The EHQ mean scores ware significantly higher in people who practice sports >150 minutes/week. EHQ score resulted to be positively correlated with endurance sport practice >150 minutes/week, with a coefficient of 2.407 (I.C.95% [0.27;4.54], p = 0.027). Analyses carried out suggested a correlation between endurance sport practice and ON. Further studies should be performed to identify diagnostic criteria and to compare different questionnaire used to assess them.
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Project description:The aim of this systematic review was to assess the effects of genetic variations and polymorphisms on endurance performance, muscle strength and injury susceptibility in competitive sports. The electronic databases PubMed and Web of Science were searched for eligible studies. The study quality was assessed using the RoBANS tool. Studies were included if they met the following criteria: (1) human study in English or German; (2) published in the period 2015-2019; (3) investigation of an association between genetic variants and endurance performance and/or muscle strength and/or endurance/strength training status as well as ligament, tendon, or muscle injuries; (4) participants aged 18-60 years and national or international competition participation; (5) comparison with a control group. Nineteen studies and one replication study were identified. Results revealed that the IGF-1R 275124 A>C rs1464430 polymorphism was overrepresented in endurance trained athletes. Further, genotypes of PPARGC1A polymorphism correlated with performance in endurance exercise capacity tests in athletes. Moreover, the RR genotype of ACTN3 R577X polymorphism, the C allele of IGF-1R polymorphism and the gene variant FTO T>A rs9939609 and/or their AA genotype were linked to muscle strength. In addition, gene variants of MCT1 (T1470A rs1049434) and ACVR1B (rs2854464) were also positively associated with strength athletes. Among others, the gene variants of the MMP group (rs591058 and rs679620) as well as the polymorphism COL5A1 rs13946 were associated with susceptibility to injuries of competitive athletes. Based on the identified gene variants, individualized training programs for injury prevention and optimization of athletic performance could be created for competitive athletes using gene profiling techniques.
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Project description:Although the variation of performance by nationality in endurance sports such as marathon has been well studied, little information exists so far on the role of nationality on performance in ultra-endurance sports. The aim of the present study was to review the role of nationality on cross-country skiing and ultra-endurance running. Scopus and PubMed were searched using the syntax "nationality AND (ultra-endurance OR ultra-marathon OR cross-country skiing) in 1/4/2020. This search identified 17 articles, whose references were further examined for relevant literature. It was observed that Russian athletes dominated ultra-endurance running and cross-country skiing races. It was shown that these races were in other countries, where it was assumed that only the best Russians competed. Potential explanations could be misuse of performance enhancing substances, historical, climate-geographical and psychophysiological (e.g., combination of genetic and social factors). In summary, recent studies found a dominance of Russian athletes in specific races (i.e., 'Comrades Marathon', 'Vasaloppet', and 'Engadin Ski Marathon') and disciplines (i.e., ultra-marathon running, cross-country skiing) over a period of several decades. Future studies are need to investigate other events and other sport disciplines to confirm this Russian dominance.
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Project description:This study aims to present a critical review of the existing literature on the effects of High-Intensity Interval Training (HIIT) on strength, speed, and endurance performance among racket sports athletes. This study conducted a systematic literature review by PRISMA guidelines. Various well-known academic and scientific databases were used for research collection, including PubMed, EBSCOhost, Scopus, Web of Science, and Google Scholar. Out of 27 relevant studies, 10 were selected for inclusion in this systematic review, all meeting the required inclusion criteria. The quality of each study was assessed using the PEDro scale, with scores ranging from 3 to 5 for the selected studies. HIIT was found to improve racket players' VO2 max (maximum oxygen uptake), running and repetitive sprint performance, jumping performance, and hitting speed during play. Current findings indicate that HIIT can significantly benefit athletic performance. Long-term HIIT allows athletes to enhance their power while improving crucial variables related to both aerobic and anaerobic endurance. This anaerobic endurance and explosive power type is particularly vital for racket sports players. For example, athletes in table tennis and badminton must exert maximum effort during high-intensity middle and back-court play. Racket athletes also need to maintain a stable state while preserving ball speed and positioning, and must quickly recover to prepare for the next rally. This training mechanism can assist athletes in honing their skills and achieving more efficient hitting quality. Therefore, this paper recommends that racket sports athletes incorporate HIIT into their regular training routines. The suggested frequency is three times per week, with each training session lasting 30-40 minutes, and a total duration of six to eight weeks. Trial registration. Systematic Review Registration: [https://inplasy.com/], identififier[INPLASY20230080].
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Project description:Applied environmental strategies for asthma control are often expensive, but may save longer-term healthcare costs. Whether these savings outweigh additional costs of implementing these strategies is uncertain.We conducted a systematic review to estimate the expenditures and savings of environmental interventions for asthma in the state of Maryland. Direct costs included hospitalizations, emergency room, and clinic visits. Indirect expenditures included costs of lost work productivity and travel incurred during the usage of healthcare services. We used decision analysis, assuming a hypothetical cohort of the approximated 49,290 pediatric individuals in Maryland with persistent asthma, to compare costs and benefits of environmental asthma interventions against the standard of care (no intervention) from the societal perspective.Three interventions among nine articles met the inclusion criteria for the systematic review: 1) environmental education using medical professionals; 2) education using non-medical personnel; and 3) multi-component strategy involving education with non-medical personnel, allergen-impermeable covers, and pest management. All interventions were found to be cost-saving relative to the standard of care. Home environmental education using non-medical professionals yielded the highest net savings of $14.1 million (95% simulation interval (SI): $-.283 million, $19.4 million), while the multi-component intervention resulted in the lowest net savings of $8.1 million (95% SI: $-4.9 million, $15.9 million). All strategies were most sensitive to the baseline number of hospitalizations in those not receiving targeted interventions for asthma.Limited environmental reduction strategies for asthma are likely to be cost-saving to the healthcare system in Maryland and should be considered for broader scale-up in other economically similar settings.
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