Ontology highlight
ABSTRACT:
SUBMITTER: Ogawa M
PROVIDER: S-EPMC7329117 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Ogawa Makiko M Shintani-Domoto Yukako Y Nagashima Yoshiki Y Ode Koji L KL Sato Aya A Shimizu Yoshihiro Y Ohashi Kenichi K Roehrl Michael H A MHA Ushiku Tetsuo T Ueda Hiroki R HR Fukayama Masashi M
PloS one 20200701 7
To clarify the significance of quantitative analyses of amyloid proteins in clinical practice and in research relating to systemic amyloidoses, we applied mass spectrometry-based quantification by isotope-labeled cell-free products (MS-QBIC) to formalin-fixed, paraffin-embedded (FFPE) tissues. The technique was applied to amyloid tissues collected by laser microdissection of Congo red-stained lesions of FFPE specimens. Twelve of 13 amyloid precursor proteins were successfully quantified, includi ...[more]