Ontology highlight
ABSTRACT:
SUBMITTER: Naranjo JD
PROVIDER: S-EPMC7329334 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Naranjo Juan Diego JD Saldin Lindsey T LT Sobieski Eric E Quijano Lina M LM Hill Ryan C RC Chan Patrick G PG Torres Crisanto C Dziki Jenna L JL Cramer Madeline C MC Lee Yoojin C YC Das Rohit R Bajwa Anant K AK Nossair Rania R Klimak Molly M Marchal Lucile L Patel Shil S Velankar Sachin S SS Hansen Kirk C KC McGrath Kevin K Badylak Stephen F SF
Science advances 20200701 27
Chronic inflammatory gastric reflux alters the esophageal microenvironment and induces metaplastic transformation of the epithelium, a precancerous condition termed Barrett's esophagus (BE). The microenvironmental niche, which includes the extracellular matrix (ECM), substantially influences cell phenotype. ECM harvested from normal porcine esophageal mucosa (eECM) was formulated as a mucoadhesive hydrogel, and shown to largely retain basement membrane and matrix-cell adhesion proteins. Dogs wit ...[more]