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InOOH Bulk Crystals and Ultrathin Nanowires under Compression.

ABSTRACT: InOOH bulk crystals and ultrathin nanowires have been investigated under high pressures by in situ synchrotron radiation X-ray diffraction measurements at ambient temperature. The anisotropic compression indicates that the b-axis is more compressible than the other two axes in InOOH under hydrostatic conditions. Two inflection points, which are associated with the hydrogen-bond strengthening, can be reflected in the plots of b/c ratio versus pressure (b/c-P plots). The size-induced enhancement of the bulk modulus can be visualized from the P-V plots. By comparing the differences in the compression of bulk InOOH and ultrathin nanowires, it is validated that the nanosize effects play an important role in the high-pressure behaviors of InOOH.

SUBMITTER: Tang S

PROVIDER: S-EPMC7331075 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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InOOH Bulk Crystals and Ultrathin Nanowires under Compression.

Tang Shunxi S Huang Xuejuan X Zhang Jian J Cui Qiliang Q

ACS omega 20200617 25

InOOH bulk crystals and ultrathin nanowires have been investigated under high pressures by in situ synchrotron radiation X-ray diffraction measurements at ambient temperature. The anisotropic compression indicates that the b-axis is more compressible than the other two axes in InOOH under hydrostatic conditions. Two inflection points, which are associated with the hydrogen-bond strengthening, can be reflected in the plots of b/c ratio versus pressure (b/c-P< ...[more]

PMID: 32637787

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Project description:BackgroundRadiation therapy is a main treatment option for cancer. Due to normal tissue toxicity, radiosensitizers are commonly used to enhance RT. In particular, heavy metal or high-Z materials, such as gold nanoparticles, have been investigated as radiosensitizers. So far, however, the related studies have been focused on spherical gold nanoparticles. In this study, we assessed the potential of ultra-thin gold nanowires as a radiosensitizer, which is the first time.MethodsGold nanowires were synthesized by the reduction of HAuCl4 in hexane. The as-synthesized gold nanowires were then coated with a layer of PEGylated phospholipid to be rendered soluble in water. Spherical gold nanoparticles coated with the same phospholipid were also synthesized as a comparison. Gold nanowires and gold nanospheres were first tested in solutions for their ability to enhance radical production under irradiation. They were then incubated with 4T1 cells to assess whether they could elevate cell oxidative stress under irradiation. Lastly, gold nanowires and gold nanoparticles were intratumorally injected into a 4T1 xenograft model, followed by irradiation applied to tumors (3 Gy/per day for three days). Tumor growth was monitored and compared.ResultsOur studies showed that gold nanowires are superior to gold nanospheres in enhancing radical production under X-ray radiation. In vitro analysis found that the presence of gold nanowires caused elevated lipid peroxidation and intracellular oxidative stress under radiation. When tested in vivo, gold nanowires plus irradiation led to better tumor suppression than gold nanospheres plus radiation. Moreover, gold nanowires were found to be gradually reduced to shorter nanowires by glutathione, which may benefit fractionated radiation.ConclusionOur studies suggest that gold nanowires are a promising type of radiosensitizer that can be safely injected into tumors to enhance radiotherapy. While the current study was conducted in a breast cancer model, the approach can be extended to the treatment of other cancer types.

Dataset Information

InOOH Bulk Crystals and Ultrathin Nanowires under Compression.

Publications

InOOH Bulk Crystals and Ultrathin Nanowires under Compression.

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