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The spectrum of COVID-19-associated dermatologic manifestations: An international registry of 716 patients from 31 countries.

ABSTRACT: BACKGROUND:Coronavirus disease 2019 (COVID-19) has associated cutaneous manifestations. OBJECTIVE:To characterize the diversity of cutaneous manifestations of COVID-19 and facilitate understanding of the underlying pathophysiology. METHODS:Case series from an international registry from the American Academy of Dermatology and International League of Dermatological Societies. RESULTS:The registry collected 716 cases of new-onset dermatologic symptoms in patients with confirmed/suspected COVID-19. Of the 171 patients in the registry with laboratory-confirmed COVID-19, the most common morphologies were morbilliform (22%), pernio-like (18%), urticarial (16%), macular erythema (13%), vesicular (11%), papulosquamous (9.9%), and retiform purpura (6.4%). Pernio-like lesions were common in patients with mild disease, whereas retiform purpura presented exclusively in ill, hospitalized patients. LIMITATIONS:We cannot estimate incidence or prevalence. Confirmation bias is possible. CONCLUSIONS:This study highlights the array of cutaneous manifestations associated with COVID-19. Many morphologies were nonspecific, whereas others may provide insight into potential immune or inflammatory pathways in COVID-19 pathophysiology.

SUBMITTER: Freeman EE

PROVIDER: S-EPMC7331510 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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The spectrum of COVID-19-associated dermatologic manifestations: An international registry of 716 patients from 31 countries.

Freeman Esther E EE McMahon Devon E DE Lipoff Jules B JB Rosenbach Misha M Kovarik Carrie C Desai Seemal R SR Harp Joanna J Takeshita Junko J French Lars E LE Lim Henry W HW Thiers Bruce H BH Hruza George J GJ Fox Lindy P LP

Journal of the American Academy of Dermatology 20200702 4

<h4>Background</h4>Coronavirus disease 2019 (COVID-19) has associated cutaneous manifestations.<h4>Objective</h4>To characterize the diversity of cutaneous manifestations of COVID-19 and facilitate understanding of the underlying pathophysiology.<h4>Methods</h4>Case series from an international registry from the American Academy of Dermatology and International League of Dermatological Societies.<h4>Results</h4>The registry collected 716 cases of new-onset dermatologic symptoms in patients with ...[more]

PMID: 32622888

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Dataset Information

The spectrum of COVID-19-associated dermatologic manifestations: An international registry of 716 patients from 31 countries.

Publications

The spectrum of COVID-19-associated dermatologic manifestations: An international registry of 716 patients from 31 countries.

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