Increased levels of VEGF-C and macrophage infiltration in lipedema patients without changes in lymphatic vascular morphology.
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ABSTRACT:
SUBMITTER: Felmerer G
PROVIDER: S-EPMC7331572 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
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Increased levels of VEGF-C and macrophage infiltration in lipedema patients without changes in lymphatic vascular morphology.
Felmerer Gunther G Stylianaki Aikaterini A Hollmén Maija M Ströbel Philipp P Stepniewski Adam A Wang Anna A Frueh Florian S FS Kim Bong-Sung BS Giovanoli Pietro P Lindenblatt Nicole N Gousopoulos Epameinondas E
Scientific reports 20200702 1
Lipedema is a chronic adipose tissue disorder characterized by the disproportional subcutaneous deposition of fat and is commonly misdiagnosed as lymphedema or obesity. The molecular determinants of the lipedema remain largely unknown and only speculations exist regarding the lymphatic system involvement. The aim of the present study is to characterize the lymphatic vascular involvement in established lipedema. The histological and molecular characterization was conducted on anatomically-matched ...[more]
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