Ontology highlight
ABSTRACT:
SUBMITTER: Nishimura T
PROVIDER: S-EPMC7331587 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Nishimura Toshihide T Nakamura Haruhiko H Yachie Ayako A Hase Takeshi T Fujii Kiyonaga K Koizumi Hirotaka H Naruki Saeko S Takagi Masayuki M Matsuoka Yukiko Y Furuya Naoki N Kato Harubumi H Saji Hisashi H
Scientific reports 20200702 1
It is unclear how epidermal growth factor receptor EGFR major driver mutations (L858R or Ex19del) affect downstream molecular networks and pathways. This study aimed to provide information on the influences of these mutations. The study assessed 36 protein expression profiles of lung adenocarcinoma (Ex19del, nine; L858R, nine; no Ex19del/L858R, 18). Weighted gene co-expression network analysis together with analysis of variance-based screening identified 13 co-expressed modules and their eigen p ...[more]