Ontology highlight
ABSTRACT:
SUBMITTER: Kambhampati M
PROVIDER: S-EPMC7331588 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Kambhampati Madhuri M Panditharatna Eshini E Yadavilli Sridevi S Saoud Karim K Lee Sulgi S Eze Augustine A Almira-Suarez M I MI Hancock Lauren L Bonner Erin R ER Gittens Jamila J Stampar Mojca M Gaonkar Krutika K Resnick Adam C AC Kline Cassie C Ho Cheng-Ying CY Waanders Angela J AJ Georgescu Maria-Magdalena MM Rance Naomi E NE Kim Yong Y Johnson Courtney C Rood Brian R BR Kilburn Lindsay B LB Hwang Eugene I EI Mueller Sabine S Packer Roger J RJ Bornhorst Miriam M Nazarian Javad J
Scientific reports 20200702 1
Children diagnosed with brain tumors have the lowest overall survival of all pediatric cancers. Recent molecular studies have resulted in the discovery of recurrent driver mutations in many pediatric brain tumors. However, despite these molecular advances, the clinical outcomes of high grade tumors, including H3K27M diffuse midline glioma (H3K27M DMG), remain poor. To address the paucity of tissue for biological studies, we have established a comprehensive protocol for the coordination and proce ...[more]