PAM staining intensity of primary neuroendocrine neoplasms is a potential prognostic biomarker.
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ABSTRACT:
SUBMITTER: Horton TM
PROVIDER: S-EPMC7331689 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
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PAM staining intensity of primary neuroendocrine neoplasms is a potential prognostic biomarker.
Horton Timothy M TM Sundaram Vandana V Lee Christine Hye-Jin CH Hornbacker Kathleen K Van Vleck Aidan A Benjamin Kaisha N KN Zemek Allison A Longacre Teri A TA Kunz Pamela L PL Annes Justin P JP
Scientific reports 20200702 1
Neuroendocrine neoplasms (NENs) are rare epithelial tumors with heterogeneous and frequently unpredictable clinical behavior. Available biomarkers are insufficient to guide individual patient prognosis or therapy selection. Peptidylglycine α-amidating monooxygenase (PAM) is an enzyme expressed by neuroendocrine cells that participates in hormone maturation. The objective of this study was to assess the distribution, clinical associations and survival implications of PAM immunoreactivity in prima ...[more]
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