Identification of circRNA-associated ceRNA network in BMSCs of OVX models for postmenopausal osteoporosis.
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ABSTRACT:
SUBMITTER: Wang H
PROVIDER: S-EPMC7331745 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
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Identification of circRNA-associated ceRNA network in BMSCs of OVX models for postmenopausal osteoporosis.
Wang Huichao H Zhou Kaifeng K Xiao Fangzhu F Huang Zhongyue Z Xu Jun J Chen Guangnan G Liu Youwen Y Gu Huijie H
Scientific reports 20200702 1
Circular RNAs (circRNAs) serve as competing endogenous RNAs (ceRNAs) and indirectly regulate gene expression through shared microRNAs (miRNAs). However, the potential circRNAs functioning as ceRNAs in osteoporosis remain unclear. The bone marrow mesenchymal stem cells (BMSCs) were isolated from ovariectomy (OVX) mice and controls. We systematically analyzed RNA-seq and miRNA-microarray data, miRNA-target interactions, and prominently coexpressed gene pairs to identify aberrantly expressed circRN ...[more]
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