Tacrolimus trough levels higher than 6 ng/mL might not be required after a year in stable kidney transplant recipients.

ABSTRACT:

Background

Little is known regarding optimal tacrolimus (TAC) trough levels after 1 year post-transplant in stable kidney transplant recipients (KTRs) who have not experienced renal or cardiovascular outcomes. This study aimed to investigate the effect of 1-year post-transplant TAC trough levels on long-term renal and cardiovascular outcomes and opportunistic infections in stable KTRs.

Methods

KTRs receiving TAC with mycophenolate-based immunosuppression who did not experience renal or cardiovascular outcomes within 1 year post-transplant were enrolled from a multicenter observational cohort study. Renal outcome was defined as a composite of biopsy-proven acute rejection, interstitial fibrosis and tubular atrophy, and death-censored graft loss. Cardiovascular outcome was def

SUBMITTER: Jung HY 

PROVIDER: S-EPMC7332007 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature