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LncRNAs as Potential Therapeutic Targets in Thyroid Cancer.

ABSTRACT: Thyroid cancer (TC) is the most common cancer of endocrine system. TC can be subdivided into 4 different entities, papillary, follicular, medullary and anaplastic thyroid cancer. Among them, anaplastic thyroid cancer has the poorest prognosis. Exploring new therapeutic approach may entail favorable prediction as well as increasing overall survival rate of patients. Long non-coding RNAs (lncRNAs), have vast implications in different cancer types. Although they are not transcribed into proteins, they can act as a harness in regulating a plethora of biological functions. They have been implicated in a decisive role in gene expression via modulation of both coding and non-coding RNAs. This article discuss the multi-facet role of lncRNA in thyroid cancer biology.
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SUBMITTER: Javed Z

PROVIDER: S-EPMC7332117 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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LncRNAs as Potential Therapeutic Targets in Thyroid Cancer.

Javed Zeeshan Z Ahmed Shah Faiez F Rajabi Sadegh S Raza Qamar Q Iqbal Zaheer Z Ullah Mukhtar M Ahmad Touqeer T Salehi Bahare B Sharifi-Rad Mehdi M Pezzani Raffaele R Yaqoob Farooq F Sadia Haleema H Iriti Marcello M Sharifi-Rad Javad J Cho William C WC

Asian Pacific journal of cancer prevention : APJCP 20200201 2

Thyroid cancer (TC) is the most common cancer of endocrine system. TC can be subdivided into 4 different entities, papillary, follicular, medullary and anaplastic thyroid cancer. Among them, anaplastic thyroid cancer has the poorest prognosis. Exploring new therapeutic approach may entail favorable prediction as well as increasing overall survival rate of patients. Long non-coding RNAs (lncRNAs), have vast implications in different cancer types. Although they are not transcribed into proteins, t ...[more]

PMID: 32102500

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