Ontology highlight
ABSTRACT:
SUBMITTER: Hilgendorf KI
PROVIDER: S-EPMC7332222 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Hilgendorf Keren I KI Johnson Carl T CT Mezger Anja A Rice Selena L SL Norris Alessandra M AM Demeter Janos J Greenleaf William J WJ Reiter Jeremy F JF Kopinke Daniel D Jackson Peter K PK
Cell 20191121 6
Adult mesenchymal stem cells, including preadipocytes, possess a cellular sensory organelle called the primary cilium. Ciliated preadipocytes abundantly populate perivascular compartments in fat and are activated by a high-fat diet. Here, we sought to understand whether preadipocytes use their cilia to sense and respond to external cues to remodel white adipose tissue. Abolishing preadipocyte cilia in mice severely impairs white adipose tissue expansion. We discover that TULP3-dependent ciliary ...[more]