Ontology highlight
ABSTRACT:
SUBMITTER: Han JH
PROVIDER: S-EPMC7332361 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Han Ji-Hun JH Yoon Jeong Seon JS Chang Da-Young DY Cho Kyung Gi KG Lim Jaejoon J Kim Sung-Soo SS Suh-Kim Haeyoung H
Molecules and cells 20200601 6
Glioblastoma multiforme (GBM) is a fatal malignant tumor that is characterized by diffusive growth of tumor cells into the surrounding brain parenchyma. However, the diffusive nature of GBM and its relationship with the tumor microenvironment (TME) is still unknown. Here, we investigated the interactions of GBM with the surrounding microenvironment in orthotopic xenograft animal models using two human glioma cell lines, U87 and LN229. The GBM cells in our model showed different features on the a ...[more]