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RICTOR/mTORC2 affects tumorigenesis and therapeutic efficacy of mTOR inhibitors in esophageal squamous cell carcinoma.


ABSTRACT: Graphical abstractThis study demonstrated that mTORC2 subunit, RICTOR, and p-AKT (Ser473) have hyperactivity in esophageal squamous cell carcinoma (ESCC) and promotes its development. Moreover, down-regulation of RICTOR can improve the sensitivity of ESCC cells to the pan-mTOR inhibitor PP242 as well as mTORC1 inhibitor RAD001.Image 1

SUBMITTER: Lu Z 

PROVIDER: S-EPMC7332809 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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