Ontology highlight
ABSTRACT:
SUBMITTER: Jost M
PROVIDER: S-EPMC7332992 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Jost Marco M Chen Yuwen Y Gilbert Luke A LA Horlbeck Max A MA Krenning Lenno L Menchon Grégory G Rai Ankit A Cho Min Y MY Stern Jacob J JJ Prota Andrea E AE Kampmann Martin M Akhmanova Anna A Steinmetz Michel O MO Tanenbaum Marvin E ME Weissman Jonathan S JS
Molecular cell 20200701 1
We recently used CRISPRi/a-based chemical-genetic screens and cell biological, biochemical, and structural assays to determine that rigosertib, an anti-cancer agent in phase III clinical trials, kills cancer cells by destabilizing microtubules. Reddy and co-workers (Baker et al., 2020, this issue of Molecular Cell) suggest that a contaminating degradation product in commercial formulations of rigosertib is responsible for the microtubule-destabilizing activity. Here, we demonstrate that cells tr ...[more]