Deciphering the underlying mechanism of Xianlinggubao capsule against osteoporosis by network pharmacology.

ABSTRACT:

Background

Xianlinggubao formula (XLGB), a Chinese State Food and Drug Administration-permitted traditional Chinese herbal medicine, has been extensively used to treat osteoporosis. Although XLGB was shown to improve bone mass in ovariectomized rats and clinically alleviate osteoporosis symptoms, its pharmacological mechanisms remain unclear.

Methods

In this study, we used a network pharmacological approach to explore the potential mechanism of XLGB in treating osteoporosis. We obtained XLGB compounds from the TCMSP and TCMID databases and identified potential targets of these compounds through target fishing based on the TCMSP and Swiss Target Prediction databases. Next, we identified the osteoporosis targets by using the CTD, TTD, GeneCards, OMIM and PharmGKB databases. Th

SUBMITTER: Bao H 

PROVIDER: S-EPMC7333287 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature