Ontology highlight
ABSTRACT:
SUBMITTER: Huang R
PROVIDER: S-EPMC7333410 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Huang Ruihao R Li Xiaoping X He Yundi Y Zhu Wen W Gao Lei L Liu Yao Y Gao Li L Wen Qin Q Zhong Jiang F JF Zhang Cheng C Zhang Xi X
Journal of hematology & oncology 20200702 1
Chimeric antigen receptor T (CAR-T) cell therapy is regarded as an effective solution for relapsed or refractory tumors, particularly for hematological malignancies. Although the initially approved anti-CD19 CAR-T therapy has produced impressive outcomes, setbacks such as high relapse rates and resistance were experienced, driving the need to discover engineered CAR-T cells that are more effective for therapeutic use. Innovations in the structure and manufacturing of CAR-T cells have resulted in ...[more]