Ontology highlight
ABSTRACT:
SUBMITTER: Etxeberria I
PROVIDER: S-EPMC7333812 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Etxeberria Iñaki I Glez-Vaz Javier J Teijeira Álvaro Á Melero Ignacio I
ESMO open 20200701 Suppl 3
CD137 (4-1BB) is a surface glycoprotein that belongs to the tumour necrosis factor receptor family (TNFRSF9). Its expression is induced on activation on a number of leucocyte types. Interestingly, for cancer immunotherapy, CD137 becomes expressed on primed T and natural killer (NK) cells, which on ligation provides powerful costimulatory signals. Perturbation of CD137 by CD137L or agonist monoclonal antibodies on activated CD8 T cells protects such antigen-specific cytotoxic T lymphocytes from a ...[more]