Ontology highlight
ABSTRACT:
SUBMITTER: Banack SA
PROVIDER: S-EPMC7333885 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Banack Sandra Anne SA Dunlop Rachael Anne RA Cox Paul Alan PA
Open biology 20200624 6
Biomarkers for amyotrophic lateral sclerosis/motor neuron disease (ALS/MND) are currently not clinically available for disease diagnosis or analysis of disease progression. If identified, biomarkers could improve patient outcomes by enabling early intervention and assist in the determination of treatment efficacy. We hypothesized that neural-enriched extracellular vesicles could provide microRNA (miRNA) fingerprints with unequivocal signatures of neurodegeneration. Using blood plasma from ALS/MN ...[more]